Huntington's disease inheritance is best described as:

• A. Autosomal recessive
• B. Autosomal dominant
• C. X-linked recessive
• D. Mitochondrial inheritance

Answer: (B)

Huntington's disease is inherited in an autosomal dominant manner. This means one copy of the mutated HTT gene is enough to cause the disorder, so an affected parent has a 50% chance of passing it to each child, regardless of the child’s sex. The condition involves a CAG repeat expansion on chromosome 4, and while onset is often in adulthood, a single mutant allele is sufficient for disease expression. It affects males and females equally and does not follow X-linked or mitochondrial inheritance patterns. Anticipation can occur, with earlier onset in future generations, particularly when the paternal chromosome is involved due to repeat expansion during spermatogenesis.