Naltrexone is contraindicated in patients with which condition?

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Multiple Choice

Naltrexone is contraindicated in patients with which condition?

Explanation:
Naltrexone is cleared by the liver and has the potential to cause hepatotoxicity. In patients with current acute hepatitis or severe hepatic impairment, metabolism is compromised and drug exposure increases, raising the risk of liver injury. That’s why liver disease is a contraindication. Baseline liver function tests are typically checked before starting and monitored during therapy, with discontinuation if liver enzymes rise significantly. Other conditions like kidney disease, heart disease, or asthma do not inherently contraindicate naltrexone, though individual patient factors always guide treatment decisions.

Naltrexone is cleared by the liver and has the potential to cause hepatotoxicity. In patients with current acute hepatitis or severe hepatic impairment, metabolism is compromised and drug exposure increases, raising the risk of liver injury. That’s why liver disease is a contraindication. Baseline liver function tests are typically checked before starting and monitored during therapy, with discontinuation if liver enzymes rise significantly. Other conditions like kidney disease, heart disease, or asthma do not inherently contraindicate naltrexone, though individual patient factors always guide treatment decisions.

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