Rett Syndrome features include which of the following statements?

• A. It is a progressive neurological developmental disorder that occurs more often in females and features decelerated head growth, with increased risk of seizures and scoliosis.
• B. It is primarily a cardiovascular disorder with rapid head growth.
• C. It is an acute infectious disease presenting in early childhood.
• D. It is a mild motor impairment with no cognitive impact.

Answer: (A)

Rett syndrome is a progressive neurodevelopmental disorder that mainly affects girls. After a period of seemingly typical development, there is regression with loss of purposeful hand skills, repetitive hand-wringing, impaired language, gait abnormalities, and cognitive impairment. A key hallmark is decelerated head growth (microcephaly), and individuals often have seizures and scoliosis as the condition progresses. This combination—progressive neurological deterioration in females, decelerated head growth, and higher risk of seizures and scoliosis—fits the statement best.

The other descriptions don’t match Rett syndrome: it is not a primary cardiovascular disorder with rapid head growth; it is not an acute infectious illness; and it is not a mild motor issue without cognitive impact.