Rett syndrome occurs predominantly in which gender?

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Multiple Choice

Rett syndrome occurs predominantly in which gender?

Explanation:
Rett syndrome is linked to mutations in MECP2 on the X chromosome and behaves as an X-linked dominant condition. Males with the mutation typically have a more severe presentation or die early, so they are not commonly identified, while females survive because X-inactivation creates a mosaic pattern of expression. This mosaicism allows the characteristic regression after a period of normal development to occur in most cases, making the syndrome predominantly seen in females. Rarely, affected males can occur in situations like mosaicism or an additional X chromosome (XXY), but these are uncommon.

Rett syndrome is linked to mutations in MECP2 on the X chromosome and behaves as an X-linked dominant condition. Males with the mutation typically have a more severe presentation or die early, so they are not commonly identified, while females survive because X-inactivation creates a mosaic pattern of expression. This mosaicism allows the characteristic regression after a period of normal development to occur in most cases, making the syndrome predominantly seen in females. Rarely, affected males can occur in situations like mosaicism or an additional X chromosome (XXY), but these are uncommon.

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