What should you check in Asian patients taking Tegretol?

Unlock all questions

This demo includes only 20 questions. Upgrade to access hundreds of questions, flashcards, exam simulations, and disable ads.

Full question bankExam simulationsFlashcards
From $24.99Unlock all

Enhance your preparation for the PMHNP Certification Exam with Georgette's resources. Delve into multiple-choice questions and detailed explanations to ensure you're ready for success. Boost your study efficiency and exam confidence today!

Multiple Choice

What should you check in Asian patients taking Tegretol?

Explanation:
Carbamazepine can trigger a life-threatening Stevens-Johnson syndrome reaction in people who carry the HLA-B*1502 allele, particularly in many Asian populations. Screening for this allele before starting Tegretol helps prevent SJS by guiding the clinician to choose a different anticonvulsant if the test is positive. The other alleles relate to different drug reactions: HLA-B*5701 is linked to abacavir hypersensitivity, G6PD deficiency pertains to drug-induced hemolysis with certain oxidant drugs, and HLA-B*1501 does not have a strong, well-established link to carbamazepine SJS in these populations.

Carbamazepine can trigger a life-threatening Stevens-Johnson syndrome reaction in people who carry the HLA-B*1502 allele, particularly in many Asian populations. Screening for this allele before starting Tegretol helps prevent SJS by guiding the clinician to choose a different anticonvulsant if the test is positive.

The other alleles relate to different drug reactions: HLA-B5701 is linked to abacavir hypersensitivity, G6PD deficiency pertains to drug-induced hemolysis with certain oxidant drugs, and HLA-B1501 does not have a strong, well-established link to carbamazepine SJS in these populations.

More Multiple Choice Questions
Subscribe

Get the latest from Examzify

You can unsubscribe at any time. Read our privacy policy