Which combination is listed as a 'false positives' pairing?

• A. Benzos and Zoloft
• B. Zoloft and Prozac
• C. Xanax and Celexa
• D. Benadryl and Zoloft

Answer: (A)

The idea being tested is identifying a pairing that is labeled as a false-positive in screening contexts. In the study resources for this PMHNP exam, a combination involving a benzodiazepine and Zoloft (sertraline) is listed as a false-positive pairing. The rationale is that certain lab screening immunoassays can cross-react with sertraline or its metabolites, producing a spurious positive result for benzodiazepines even if a benzodiazepine isn’t actually present. That labeling signals you should not rely on a positive screen to confirm the presence of a benzodiazepine when sertraline is part of the regimen.

The other options do not carry that false-positive flag in the materials. Two SSRIs together are a clinically discussed combination with risks (like serotonin syndrome) but not a false-positive labeling in this context; a benzodiazepine with Celexa is another benzo-SSRI pairing without that specific screening interference tag; and Benadryl with Zoloft is simply an antihistamine-SSRI combo without the false-positive designation in the resource.

So, the benzodiazepine with Zoloft pairing stands out as the one listed as a false-positive pairing.