Which epidermal reactions are specifically linked to Tegretol or Lamictal in the material?

• A. Toxic epidermal necrolysis and Stevens-Johnson syndrome
• B. Psoriasis and eczema
• C. Acne and dermatitis
• D. Urticaria and angioedema

Answer: (A)

Severe drug-induced skin reactions—Stevens-Johnson syndrome and toxic epidermal necrolysis—are the reactions most specifically linked to Tegretol and Lamictal. Carbamazepine and lamotrigine are anticonvulsants known to trigger this immune-mediated blistering process, which can start with nonspecific symptoms and a painful rash and may progress to widespread skin detachment with mucosal involvement. Because of this risk, dosing is started low and titrated slowly (especially with lamotrigine), and any new rash requires immediate evaluation and withdrawal of the medication. The other options describe conditions that are not the classic epidermal reactions associated with these drugs (they are more general inflammatory or allergic skin conditions).