Which of the following lists the symptoms commonly seen in Huntington's disease?

• A. Tremors, clumsiness, memory loss, mood changes, involuntary movements, and difficulty swallowing or speaking
• B. Fever, rash, and joint pain
• C. Chronic cough and shortness of breath
• D. Seizures and coma

Answer: (A)

Huntington's disease typically presents with a combination of motor, cognitive, and psychiatric symptoms, along with bulbar involvement as the disease progresses. Motor features include involuntary movements (chorea) and noticeable tremor or clumsiness, while cognitive decline manifests as memory loss. Psychiatric changes such as mood fluctuations or depression are common, and as the disease advances, swallowing and speaking become difficult due to bulbar dysfunction. The list that includes tremors, clumsiness, memory loss, mood changes, involuntary movements, and difficulty swallowing or speaking captures these motor, cognitive, and bulbar features that define Huntington's. The other option sets describe symptoms more typical of other conditions (inflammatory or infectious processes, respiratory diseases, or acute neurological emergencies), which do not fit Huntington's pattern.