Which statement is true about the three antipsychotics with very low weight gain effects?

• A. Geodon, Abilify, and Latuda
• B. Olanzapine, Quetiapine, Clozapine
• C. Haloperidol, Chlorpromazine, Lurasidone
• D. Risperidone, Ziprasidone, Paliperidone

Answer: (A)

Weight gain risk varies widely among antipsychotics, with some drugs driving substantial metabolic changes while others are largely weight-neutral. The trio known for very low weight gain effects includes ziprasidone, aripiprazole, and lurasidone. Geodon (ziprasidone), Abilify (aripiprazole), and Latuda (lurasidone) are commonly cited as having the most favorable metabolic profiles, in contrast to agents like olanzapine, quetiapine, and clozapine that are associated with greater weight gain and metabolic risk. Keep in mind that individual responses vary and ongoing metabolic monitoring is important, but these three are the best-supported choices for minimal weight gain. Ziprasidone can carry QT prolongation risk, and aripiprazole and lurasidone have their own profile considerations, but the overall weight gain risk is lower with these agents.