Which statement is true regarding Lamictal and aseptic meningitis?

• A. Lamictal can be associated with aseptic meningitis
• B. Lamictal never causes meningitis
• C. Lamictal causes bacterial meningitis
• D. Lamictal prevents meningitis

Answer: (A)

Lamotrigine can be associated with aseptic meningitis, a rare adverse reaction. This condition presents with meningitis-like symptoms such as headache, fever, and neck stiffness, along with CSF findings that show pleocytosis but negative bacterial cultures. It most often appears within days to weeks after starting or increasing the dose. Because it mimics infectious meningitis, recognizing it is crucial so that the medication can be stopped promptly and avoid unnecessary antibiotics or invasive workups. Stopping lamotrigine typically leads to symptom resolution within a few days, and re‑exposure can lead to recurrence, so re‑challenge is avoided. It is not caused by bacteria, and lamotrigine does not prevent meningitis.