Why is Clozaril used?

• A. Treatment-resistant schizophrenia, improves suicidal ideation and negative symptoms
• B. First-line treatment for all forms of schizophrenia
• C. To treat major depressive disorder
• D. To prevent bipolar mania

Answer: (A)

Clozapine is used mainly for schizophrenia that has not responded to other antipsychotics and has a unique anti-suicidal effect. It’s particularly effective in treatment-resistant cases and can improve negative symptoms that often persist despite other medications. Because of the risk of serious side effects like agranulocytosis, it is not first-line and requires ongoing blood monitoring and a careful safety program. It’s also not typically used for major depressive disorder or to prevent bipolar mania. So the best fit is its use in treatment-resistant schizophrenia with an added benefit of reducing suicidality and improving negative symptoms.